Puberty is a period of maturation which occurs during adolescence, involving the development of reproductive glands, external genitalia as well as secondary sex characteristics.
Onset of puberty:
These values are averages, however, and the age of onset may vary considerably.
Hypothyroidism - increased TSH levels linked with precocious puberty
Early development of primary and secondary sexual characteristics.
1st line - serum gonadotropin (LH and FSH) levels.
Imaging - perform an ultrasound of the testicles, pelvis and abdomen.
Further bloods - TSH, T3/T4, β-HCG, 21β-hydroxylase
The underlying cause must ultimately be addressed, however:
GnRH agonist i.e. goserelin can be used. It binds to the GnRH receptors on the pituitary gland, initially causing LH and FSH production to increase, however the receptors then become desensitised to GnRH and as a release gonadotropin release decreases.
Treatment for peripheral precocious puberty depends on the underlying cause.